Professor Philippe Schucht

Neurosurgeon, Head of Neurosurgical Oncology, University Hospital Bern
  • Bern, CH
  • En, Fr, De
  • Best at: Low grade Glioma - Insular Glioma - Glioblastoma surgery

Professor Philippe Schucht leads the Neurosurgical Oncology Team at the University Hospital of Bern, the interdisciplinary Tumor Board and is a coordinator of the University Cancer Center UCI. He specialises in Surgery for intrinsic brain tumors such as low grade glioma (astrocytoma, oligodendroglioma) and glioblastoma. He` s a founder and member of numerous neurosurgical organisations and is deeply involved in humanitarian activities through the Swiss Neurosurgeons International, especially in Myanmar.

Statistics.

Achievements of Professor Philippe Schucht

Trustedoctor credentials
-
Clinical endorsements
26
Articles
113
Scientific
co-authors
Trustedoctor credentials
4
General specialty
3
Subspeciality
Languages

About.

Information about Professor Philippe Schucht

Timeline
Place
Country
Position
Focus
2015-2016
Harvard Business School
United States
Executive
PLD
2006-2010
University of Bern, Inselspital
Switzerland
Resident
Neurosurgery
2006
Schulthess Klinik, Zurich
Switzerland
Resident
Neurology/Neurosurgery
2005
University of Zurich
Switzerland
Resident
Neuroradiology
2004-2005
University of Bern, Inselspital
Switzerland
Resident
Neurosurgery
2003-2004
Affoltern am Albis
Switzerland
Resident
General Surgery
1996-2002
University of Zurich
Switzerland
MD
Medical Studies
Timeline
Place
Country
Position
Focus
2016
University of Bern
Switzerland
Assistant Professor
Neurosurgery
2015
University of Bern
Switzerland
Leit. Arzt (Exec. Cons.)
Neurosurgery
2014
University of Bern
Switzerland
Oberarzt I (Sen. Cons.)
Neurosurgery
2013
University of Bern
Switzerland
Oberarzt I (Sen. Cons.)
Neurosurgery
2012
UCSF, San Francisco, USA
United States
Fellow
Neurosurgery
2011
Centre Hospitalier Gui de Chauliac
France
Fellow
Neurosurgery
2010
University of Bern
Switzerland
Oberarzt II (Consultant)
Neurosurgery
Timeline
Place
Organization
Position
Since 2016
Myanmar
University Hospital Yangon
Honorary Professor of Neurosurgery
Since 2016
Myanmar
University Hospital of Mandalay
Visiting Professor of Neurosurgery
Since 2015
Europe
European Association of Neurosurgeons
Member
Since 2012
Switzerland
Swiss Neurosurgeons International
Founder
Since 2012
Switzerland
Swiss Glioma Network
Secretary
Since 2009
Switzerland
Swiss Society of Neurosurgery
Founding member and President
Since 2005
Switzerland
Swiss young neurosurgeons society
Founder, Former President
Timeline
Description
Collaboration
Since 2012
Non-invasive function localization for minimal brain surgery; collaboration with Professor Mitch Berger of the neurosurgical department of the university of San Francisco, USA
Prof. Mitch Berger, USA
Since 2012
HORAO - intraoperative Visualization of cerebral tumors; collaboration with the Swiss National Fund and Crowd Innovation Lab (Karim Lakhani, Harvard)
Swiss National Fund; Karim Lakhani, Harvard, USA
Since 2011
Intra-operative funcion localization for surgery in eloquent brain areas; collaboration with Professor Hugues Duffau, University of Montpellier, France
Prof. Hugues Duffau, France
Since 2011
Bio-mathematical gliomas modeling: collaboration with Professor Victor Mendes of the mathematical department of the university of Ciudad Real, Spain
Prof. Victor Mendes, Spain
Timeline
Place
Award
Position
-
-
-
-

Clinical Experience.

General speciality (4)
Patients per year
Patients total
general brain tumor surgery
50-100
-
glioma surgery
50-100
-
skull base surgery
50-100
-
pediatric neurosurgery
50-100
-
Sub-speciality (3)
Patients per year
Patients total
astrocytoma
50-100
-
glioblastoma
50-100
-
ependymoma
50-100
-

Skills & Endorsements.

General specialty
general brain tumor surgery
glioma surgery
skull base surgery
spinal cord surgery
pediatric neurosurgery

Academic research.

26
Total articles
  • surgery - 23
  • radiotherapy - 1
16
brain cancer articles 5.33 Impact Factor
  • brain neoplasms - 16
  • surgery - 14
Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection.

While standards for the treatment of newly diagnosed glioblastomas exist, therapeutic regimens for tumor recurrence remain mostly individualized. The role of a surgical resection of recurrent glioblastomas remains largely unclear at present. This study aimed to assess the effect of repeated resection of recurrent glioblastomas on patient survival.

Extending resection and preserving function: modern concepts of glioma surgery.

Recent studies have demonstrated that the improved prognosis derived from resection of gliomas largely depends on the extent and quality of the resection, making maximum but safe resection the ultimate goal. Simultaneously, technical innovations and refined neurosurgical methods have rapidly improved efficacy and safety. Because gliomas derive from intrinsic brain cells, they often cannot be visually distinguished from the surrounding brain tissue during surgery. In order to appreciate the full extent of their solid compartment, various technologies have recently been introduced. However, radical resection of infiltrative glioma puts neurological function at risk, with potential detrimental consequences for patients' survival and quality of life. The allocation of various neurological functions within the brain varies in each patient and may undergo additional changes in the presence of a tumour (brain plasticity), making intra-operative localisation of eloquent areas mandatory for preservation of essential brain functions. Combining methods that visually distinguish tumour tissue and detect tissues responsible for critical functions now enables resection of tumours in brain regions that were previously considered off-limits, and benefits patients by enabling a more radical resection, while simultaneously lowering the risk of neurological deficits. Here we review recent and expected developments in microsurgery for glioma and their respective benefits.

Intraoperative monopolar mapping during 5-ALA-guided resections of glioblastomas adjacent to motor eloquent areas: evaluation of resection rates and neurological outcome.

Resection of glioblastoma adjacent to motor cortex or subcortical motor pathways carries a high risk of both incomplete resection and postoperative motor deficits. Although the strategy of maximum safe resection is widely accepted, the rates of complete resection of enhancing tumor (CRET) and the exact causes for motor deficits (mechanical vs vascular) are not always known. The authors report the results of their concept of combining monopolar mapping and 5-aminolevulinic acid (5-ALA)-guided surgery in patients with glioblastoma adjacent to eloquent tissue.

Predicting the "usefulness" of 5-ALA-derived tumor fluorescence for fluorescence-guided resections in pediatric brain tumors: a European survey.

Five-aminolevulinic acid (Gliolan, medac, Wedel, Germany, 5-ALA) is approved for fluorescence-guided resections of adult malignant gliomas. Case reports indicate that 5-ALA can be used for children, yet no prospective study has been conducted as of yet. As a basis for a study, we conducted a survey among certified European Gliolan users to collect data on their experiences with children.

Delay effects in the response of low-grade gliomas to radiotherapy: a mathematical model and its therapeutical implications.

Low-grade gliomas (LGGs) are a group of primary brain tumours usually encountered in young patient populations. These tumours represent a difficult challenge because many patients survive a decade or more and may be at a higher risk for treatment-related complications. Specifically, radiation therapy is known to have a relevant effect on survival but in many cases it can be deferred to avoid side effects while maintaining its beneficial effect. However, a subset of LGGs manifests more aggressive clinical behaviour and requires earlier intervention. Moreover, the effectiveness of radiotherapy depends on the tumour characteristics. Recently Pallud et al. (2012. Neuro-Oncology, 14: , 1-10) studied patients with LGGs treated with radiation therapy as a first-line therapy and obtained the counterintuitive result that tumours with a fast response to the therapy had a worse prognosis than those responding late. In this paper, we construct a mathematical model describing the basic facts of glioma progression and response to radiotherapy. The model provides also an explanation to the observations of Pallud et al. Using the model, we propose radiation fractionation schemes that might be therapeutically useful by helping to evaluate tumour malignancy while at the same time reducing the toxicity associated to the treatment.

Multi-modal glioblastoma segmentation: man versus machine.

Reproducible segmentation of brain tumors on magnetic resonance images is an important clinical need. This study was designed to evaluate the reliability of a novel fully automated segmentation tool for brain tumor image analysis in comparison to manually defined tumor segmentations.

Low-threshold monopolar motor mapping for resection of lesions in motor eloquent areas in children and adolescents.

Resection of lesions close to the primary motor cortex (M1) and the corticospinal tract (CST) is generally regarded as high-risk surgery due to reported rates of postoperative severe deficits of up to 50%. The authors' objective was to determine the feasibility and safety of low-threshold motor mapping and its efficacy for increasing the extent of lesion resection in the proximity of M1 and the CST in children and adolescents.

Continuous dynamic mapping of the corticospinal tract during surgery of motor eloquent brain tumors: evaluation of a new method.

The authors developed a new mapping technique to overcome the temporal and spatial limitations of classic subcortical mapping of the corticospinal tract (CST). The feasibility and safety of continuous (0.4-2 Hz) and dynamic (at the site of and synchronized with tissue resection) subcortical motor mapping was evaluated.

5-ALA complete resections go beyond MR contrast enhancement: shift corrected volumetric analysis of the extent of resection in surgery for glioblastoma.

The technique of 5-aminolevulinic acid (5-ALA) tumor fluorescence is increasingly used to improve visualization of tumor tissue and thereby to increase the rate of patients with gross total resections. In this study, we measured the resection volumes in patients who underwent 5-ALA-guided surgery for non-eloquent glioblastoma and compared them with the preoperative tumor volume.

Surgery for low-grade glioma infiltrating the central cerebral region: location as a predictive factor for neurological deficit, epileptological outcome, and quality of life.

A main concern with regard to surgery for low-grade glioma (LGG, WHO Grade II) is maintenance of the patient's functional integrity. This concern is particularly relevant for gliomas in the central region, where damage can have grave repercussions. The authors evaluated postsurgical outcomes with regard to neurological deficits, seizures, and quality of life.

The warning-sign hierarchy between quantitative subcortical motor mapping and continuous motor evoked potential monitoring during resection of supratentorial brain tumors.

Mapping and monitoring are believed to provide an early warning sign to determine when to stop tumor removal to avoid mechanical damage to the corticospinal tract (CST). The objective of this study was to systematically compare subcortical monopolar stimulation thresholds (1-20 mA) with direct cortical stimulation (DCS)-motor evoked potential (MEP) monitoring signal abnormalities and to correlate both with new postoperative motor deficits. The authors sought to define a mapping threshold and DCS-MEP monitoring signal changes indicating a minimal safe distance from the CST.

Gross total resection rates in contemporary glioblastoma surgery: results of an institutional protocol combining 5-aminolevulinic acid intraoperative fluorescence imaging and brain mapping.

Complete resection of contrast-enhancing tumor has been recognized as an important prognostic factor in patients with glioblastoma and is a primary goal of surgery. Various intraoperative technologies have recently been introduced to improve glioma surgery.

Low-threshold monopolar motor mapping for resection of primary motor cortex tumors.

Microsurgery within eloquent cortex is a controversial approach because of the high risk of permanent neurological deficit. Few data exist showing the relationship between the mapping stimulation intensity required for eliciting a muscle motor evoked potential and the distance to the motor neurons; furthermore, the motor threshold at which no deficit occurs remains to be defined.

Connections.

Map of connections

113
Scientific
co-authors
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